Effect of Scorbic acid on Hyperlipidemia

هیپرلیپیدمی یکی از مهم ترین ریسک فاکتورهای آترواسکروزیس می باشد که عامل مهمی در بروز بیماریهای قلبی و سکته مغزی است. اگر چه داروهای مفیدی برای کاهش چربی های خون وارد بازار شده ولی تلاش برای یافتن مواد موثرتر و کم عارضه تر همچنان ادامه دارد. با توجه به گزارشات پراکنده مبنی بر احتمال تـأثیر مثبت مصرف ویتامین C بر کاهش چـربی های خون در این تحـقیق تاثیر این ویتامین بر تری گلیـسرید، کلستـرول، لیپو پروتئین با چـگالی پائین (LDL) و لیپو پروتئین با چگالی بالا (HDL)، در بیماران مصرف کننده لیپیدمی ، مورد بررسی قرار گرفت. در یک کارآزمایی بالینی دو سوکور دو گروه 31 نفره از بیماران مبتلا به هیپرلیپیدمی مصرف کننده لواستاتین انتخاب و پس از انجام آزمایشات مربوط به چربی خون، به گروه مورد روزانه 1000 میلی گرم ویتامین C و به گروه شاهد پلاسبو اضافه شد. پس از 10 هفته مجدداً خون بیماران مورد آزمایش قرار گرفت. نتایج مطالعه نشان داد در هیچ یک از فاکتورهای تری گلیسرید، کلسترول و LDL از نظر آماری تغییر حاصل نشده، ولی میزان HDL بیماران تحت درمان با ویتامین C در مقایسه با گروهی که پلاسبو دریافت کرده بودند افزایش پیدا کرده بود (05/0

Medicinal plants for renal injury prevention.

It has been estimated that about 20% of men and 25% of women between the ages of 65 and 74 have some degrees of chronic kidney. This complication is attributed to oxidative stress. Oxidative stress is an important factor contributing to kidney damage by increasing production of oxidants, particularly insufficiency of endogenous antioxidant defense system. Medicinal plants antioxidants are able to ameliorate oxidative induced kidney damage by reduction of lipid peroxidation and enhancement of scavenging ability of antioxidant defense system. Supplementation of medicinal plants antioxidants might be considered important remedies to abrogate pathology of oxidative stress induced kidney damage, however, single antioxidants do not act the same and might not be beneficial

Serum lipoprotein (a) and atherosclerotic changes in hemodialysis patients.

INTRODUCTION Lipoprotein (a) [Lp(a)] is considered as a risk factor for coronary atherosclerotic disorder and an increase in plasma Lp(a) concentration is usually seen in patients with kidney failure. OBJECTIVES We aimed in this study to evaluate the impact of plasma Lp(a) level on early changes of atherosclerotic vessels in stable hemodialysis (HD) patients. PATIENTS AND METHODS In this clinical study 61 patients (50 non-diabetic (F=20 M=30) and 11 diabetic HD patients), receiving maintenance hemodialysis were included and serum Lp(a) was measured. B-mode ultrasonography of carotid intima-media thickness (cIMT) was also determined. RESULTS The mean ±SD of patients Lp(a) was 58.5±19 mg/dL. The mean ±SD of diabetic patients' Lp(a) was 62±12mg/dL and for nondiabetic ones was 57.7± 20mg/dL. In this study the thickening of Intima-media complex in diabetic group was more than non-diabetics, and no significant difference was found of Lp(a) between diabetic and non diabetic HD patients. There was a significant positive association between serum Lp(a) and cIMT. CONCLUSION Accelerated atherosclerosis seen in diabetic hemodialysis patients. Lp(a) might have an important role in progression of atherosclerosis to accelerate progressive atherosclerosis in these patients

Medicinal plants and secondary metabolites for leech control

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Protective effect of artichoke (Cynara scolymus) leaf extract against lead toxicity in rat

Context: Artichoke, Cynara scolymus L. (Asteraceae), has many natural antioxidants and multiple pharmacological actions. Recent studies have shown that it has antitoxic activity. Objective: Lead (Pb) is a dangerous environmental toxicant that induces a broad range of dysfunctions in human. This study evaluated the protective effect of the hydroethanolic extract of artichoke against altered biochemical parameters in rats fed with lead-containing diet. Materials and methods: Thirty-two rats were randomly divided into four groups. The first (control) group received standard diet. The second, third and fourth groups received 500 mg lead/kg diet, 500 mg lead/kg diet plus 300 mg/kg b.w. artichoke extract daily, and 500 mg lead/kg diet plus 1 mg vitamin C/100 g b.w. daily for 6 weeks, respectively. Serum lead, lipoprotein profile, ALT (alanine transaminase), AST (aspartate transaminase), ALP (alkaline phosphatase), malondialdehyde (MDA) and liver histopathology assessments were conducted. Results: Serum lead, triglyceride (TG), VLDL, ALT, AST, ALP and MDA levels decreased significantly (p 0.05). Furthermore, the liver histopathology in rats treated with artichoke showed a mild degree of lymphocyte infiltration that was relatively comparable to the control and vitamin C-treated groups. Discussion and conclusion: These results clearly show that the artichoke extract in lead-poisoned rats has suitable chelating properties for the reduction of blood lead levels